Specific code 2014 ICD-9-CM Diagnosis Code 281.0
Pernicious anemia
  • Billable Code
  • ICD-9-CM 281.0 will be replaced by an equivalent ICD-10-CM code (or codes) when the United States transitions from ICD-9-CM to ICD-10-CM on October 1, 2015.
  • ICD-9-CM 281.0 is a billable medical code that can be used to specify a diagnosis on a reimbursement claim.
Disease Synonyms
  • Anemia, pernicious
Clinical Information
  • (per-nish-us a-nee-mee-a) a type of anemia (low red blood cell count) caused by the body's inability to absorb vitamin b12.
  • Anemia due to poor intestinal absorption of vitamin b12 caused by defective production of intrinsic factor (a carrier protein) by the gastric mucosa.
281.0 Excludes
  • combined system disease without mention of anemia (266.2)
  • subacute degeneration of spinal cord without mention of anemia (266.2)
Applies To
  • Anemia:
    • Addison's
    • Biermer's
    • congenital pernicious
  • Congenital intrinsic factor [Castle's] deficiency
Convert to ICD-10-CM: 281.0 converts approximately to:
  • 2014 ICD-10-CM D51.0 Vitamin B12 deficiency anemia due to intrinsic factor deficiency
ICD-9-CM Volume 2 Index entries containing back-references to 281.0:
  • Addison's
    • anemia (pernicious) 281.0
  • Addison-Biermer anemia (pernicious) 281.0
  • Anemia 285.9
    • Addison's (pernicious) 281.0
    • Addison-Biermer (pernicious) 281.0
    • Biermer's (pernicious) 281.0
    • congenital (following fetal blood loss) 776.5
      • aplastic 284.01
      • due to isoimmunization NEC 773.2
      • Heinz-body 282.7
      • hereditary hemolytic NEC 282.9
      • nonspherocytic
      • pernicious 281.0
      • spherocytic (see also Spherocytosis) 282.0
    • cytogenic 281.0
    • malignant (progressive) 281.0
    • pernicious (combined system disease) (congenital) (dorsolateral spinal degeneration) (juvenile) (myelopathy) (neuropathy) (posterior sclerosis) (primary) (progressive) (spleen) 281.0
      • of or complicating pregnancy 648.2
    • progressive 285.9
      • malignant 281.0
      • pernicious 281.0
    • vitamin
      • B6-responsive 285.0
      • B12 deficiency (dietary) 281.1
        • pernicious 281.0
  • Biermer's anemia or disease (pernicious anemia) 281.0
  • Congenital - see also condition
    • intrinsic factor deficiency 281.0
  • Deficiency, deficient
    • intrinsic factor (Castle's) (congenital) 281.0
  • Disease, diseased - see also Syndrome
    • Addison's (bronze) (primary adrenal insufficiency) 255.41
      • anemia (pernicious) 281.0
      • tuberculous (see also Tuberculosis) 017.6
    • Biermer's (pernicious anemia) 281.0
    • Runeberg's (progressive pernicious anemia) 281.0
  • Runeberg's disease (progressive pernicious anemia) 281.0
ICD-9-CM codes are used in medical billing and coding to describe diseases, injuries, symptoms and conditions. ICD-9-CM 281.0 is one of thousands of ICD-9-CM codes used in healthcare. Although ICD-9-CM and CPT codes are largely numeric, they differ in that CPT codes describe medical procedures and services. Can't find a code? Start at the root of ICD-9-CM, check the 2014 ICD-9-CM Index or use the search engine at the top of this page to lookup any code.