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2008 ICD-9-CM Volume 1 Diagnosis Codes Home > Diseases Of The Nervous System And Sense Organs 320-389 > Other Disorders Of The Central Nervous System 340-349 > 2008 ICD-9-CM Diagnosis 340 Multiple sclerosis  On October 1, 2008 the 2009 ICD-9-CM codes came into effect. Therefore, this code may be out of date. The 2009 version of ICD-9-CM 340 can be accessed here. A disorder of the central nervous system marked by weakness, numbness, a loss of muscle coordination, and problems with vision, speech, and bladder control. Multiple sclerosis is thought to be an autoimmune disease in which the body's immune system destroys myelin. Myelin is a substance that contains both protein and fat (lipid), serving as a nerve insulator and helping in the transmission of nerve signals. An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903) 340 is a specific code that can be used to specify a diagnosis 340 contains 23 index entries 340 also known as: Disseminated or multiple sclerosis: NOS brain stem cord generalized Index entries containing 340: Demyelination, demyelinization global 340 Diabetes, diabetic (brittle) (congenital) (familial) (mellitus) (poorly controlled) (severe) (slight) (without complication) 250.0 dorsal sclerosis 250.6 [340] Disease, diseased - see also Syndrome demyelinating, demyelinizating (brain stem) (central nervous system) 341.9 multiple sclerosis 340 Myelosclerosis 289.89 disseminated, of nervous system 340 Sclerose en plaques 340 Sclerosis, sclerotic ascending multiple 340 brain (general) (lobular) 341.9 disseminated 340 insular 340 miliary 340 multiple 340 bulbar, progressive 340 cerebrospinal 340 disseminated 340 multiple 340 combined (spinal cord) - see also Degeneration, combined multiple 340 disseminated 340 dorsal 340 insular 340 pancreas 251.8 multiple (brain stem) (cerebral) (generalized) (spinal cord) 340 plaques 340 spinal (cord) (general) (progressive) (transverse) 336.8 combined - see also Degeneration, combined multiple 340 disseminated 340 multiple 340