Specific code 2015 ICD-9-CM Diagnosis Code 288.4
Hemophagocytic syndromes
  • 2015
  • Billable Thru Sept 30/2015
  • Non-Billable On/After Oct 1/2015

  • ICD-9-CM 288.4 is a billable medical code that can be used to indicate a diagnosis on a reimbursement claim, however, 288.4 should only be used for claims with a date of service on or before September 30, 2015. For claims with a date of service on or after October 1, 2015, use an equivalent ICD-10-CM code (or codes).
Convert to ICD-10-CM: 288.4 converts approximately to:
  • 2015/16 ICD-10-CM D76.1 Hemophagocytic lymphohistiocytosis
  • 2015/16 ICD-10-CM D76.2 Hemophagocytic syndrome, infection-associated
  • 2015/16 ICD-10-CM D76.3 Other histiocytosis syndromes
Approximate Synonyms
  • Familial hemophagocytic lymphohistiocytosis
  • Hemophagocytic lymphohistiocytosis
  • Hemophagocytic syndrome
  • Hemophagocytic syndrome, infection-associated
  • Infection w hemophagocytic syndrome
Clinical Information
  • A group of related disorders characterized by lymphocytosis; histiocytosis; and hemophagocytosis. The two major forms are familial and reactive
  • A rare but potentially life-threatening disorder characterized by the proliferation of histiocytes and macrophages and phagocytosis of red blood cells, white blood cells, and platelets. It may be inherited or secondary, due to infections, autoimmune disorders, or underlying malignancies. Signs and symptoms include fever, lymphadenopathy, hepatomegaly, splenomegaly, and pancytopenia
  • A rare disorder in which histiocytes and lymphocytes (types of white blood cells) build up in organs including the skin, spleen, and liver, and destroy other blood cells. Hemophagocytic lymphohistiocytosis may be inherited or caused by certain conditions or diseases, including infections, immunodeficiency (inability of the body to fight infections), and cancer
Applies To
  • Familial hemophagocytic lymphohistiocytosis
  • Familial hemophagocytic reticulosis
  • Hemophagocytic syndrome, infection-associated
  • Histiocytic syndromes
  • Macrophage activation syndrome
ICD-9-CM Volume 2 Index entries containing back-references to 288.4:
  • Family, familial - see also condition
    • hemophagocytic
      • lymphohistiocytosis 288.4
      • reticulosis 288.4
  • Hemophagocytic syndrome 288.4
    • infection-associated 288.4
  • Histiocytic syndromes 288.4
  • Lymphohistiocytosis, familial hemophagocytic 288.4
  • Macrophage activation syndrome 288.4
  • Reticulosis (skin)
    • familial hemophagocytic 288.4
  • Syndrome - see also Disease
    • hemophagocytic 288.4
      • infection-associated 288.4
    • histiocytic 288.4
    • macrophage activation 288.4
ICD-9-CM codes are used in medical billing and coding to describe diseases, injuries, symptoms and conditions. ICD-9-CM 288.4 is one of thousands of ICD-9-CM codes used in healthcare. Although ICD-9-CM and CPT codes are largely numeric, they differ in that CPT codes describe medical procedures and services. Can't find a code? Start at the root of ICD-9-CM, check the 2015 ICD-9-CM Index or use the search engine at the top of this page to lookup any code.