2015 ICD-9-CM Diagnosis Code 277.2
Other disorders of purine and pyrimidine metabolism
- 2015
- Billable Thru Sept 30/2015
- Non-Billable On/After Oct 1/2015
- ICD-9-CM 277.2 is a billable medical code that can be used to indicate a diagnosis on a reimbursement claim, however, 277.2 should only be used for claims with a date of service on or before September 30, 2015. For claims with a date of service on or after October 1, 2015, use an equivalent ICD-10-CM code (or codes).
Convert to ICD-10-CM:
277.2 converts approximately to:
- 2015/16 ICD-10-CM E79.1 Lesch-Nyhan syndrome
Or:
- 2015/16 ICD-10-CM E79.8 Other disorders of purine and pyrimidine metabolism
Approximate Synonyms
- Adenine phosphoribosyl transferase deficiency type I
- Adenine phosphoribosyl transferase deficiency type II
- Adenine phosphoribosyltransferase deficiency, Japanese type
- Adenosine deaminase deficiency
- Adenylosuccinate lyase deficiency
- beta-Aminoisobutyricaciduria
- Combined molybdoflavoprotein enzyme deficiency
- Cytosine diphosphate choline phosphotransferase deficiency
- Decreased uric acid level
- Dihydropyrimidinase deficiency
- Dihydrouracil dehydrogenase deficiency
- Disorder of purine and pyrimidine metabolism
- Disorder of purine metabolism
- Disorder of pyrimidine metabolism
- Hereditary orotic aciduria, type 2
- Hereditary xanthinuria
- Hooft's syndrome
- Hyperuricuria
- Hypouricemia
- Inosine triphosphate pyrophosphohydrolase deficiency
- Isolated xanthine oxidase deficiency
- Lesch Nyhan syndrome
- Lesch-Nyhan syndrome
- Muscle AMP deaminase deficiency
- Partial hypoxanthine-guanine phosphoribosyltransferase deficiency
- Purine and pyrimidine metabolism disorder
- Purine nucleoside phosphorylase deficiency
- Purine-nucleoside phosphorylase deficiency
- Ribose-phosphate pyrophosphokinase overactivity
- Secondary orotic aciduria
- Thiopurine methyltransferase deficiency
- Uridine monophosphate hydrolase deficiency
- Xanthinuria
Clinical Information
- An inborn error of metabolism resulting from a deficiency of hypoxanthine-guanine phosphoribosyltransferase (ec 2.4.2.8) with increased conversion of glycine to uric acid with excessive purine synthesis and hyperuricemia. Patients are normal at birth but begin to show hypertonicity at about 4 months and irritability and other neurological symptoms become apparent during the second year of life, the child becoming gradually more aggressive and self-destructive, banging his head, biting the lower lip and, less commonly, the upper lip, cheeks, fingers, and hands, sometimes using the fingers to mutilate his ears and nose. Associated disorders include spastic cerebral palsy, choreoathetosis, renal uric acid calculi, gouty tophi, and uric acid nodules. Mental retardation is common but normal intelligence occurs in some cases
- Rare x-linked disorder of purine metabolism, due to deficiency of hypoxanthine phosphoribosyltransferase; affected individuals are normal in the first year of life and then develop psychomotor retardation, extrapyramidal movement disorders, progressive spasticity, and seizures; self-destructive behaviors such as biting of fingers and lips are seen frequently; intellectual impairment may also occur but is typically not severe; elevation of uric acid in the serum leads to the development of renal calculi and gouty arthritis
277.2 Excludes
Applies To
- Hypoxanthine-guanine-phosphoribosyltransferase deficiency [HG-PRT deficiency]
- Lesch-Nyhan syndrome
- Xanthinuria
beta-aminoisobutyric (BAIB) 277.2
adenosine deaminase 277.2
