Specific code 2014 ICD-9-CM Diagnosis Code 273.4
Alpha-1-antitrypsin deficiency
  • Billable Code
  • Short description: Alpha-1-antitrypsin def.
  • ICD-9-CM 273.4 will be replaced by an equivalent ICD-10-CM code (or codes) when the United States transitions from ICD-9-CM to ICD-10-CM on October 1, 2015.
  • ICD-9-CM 273.4 is a billable medical code that can be used to specify a diagnosis on a reimbursement claim.
Disease Synonyms
  • Alpha 1 antitrypsin deficiency
Clinical Information
  • A genetic disorder characterized by decreased alpha-1 antitrypsin activity in the lungs and blood and deposition of alpha-1 antitrypsin protein in the hepatocytes. These abnormalities result from defective production of alpha-1 antitrypsin and lead to the development of emphysema, cirrhosis, and liver failure.
  • Alpha-1 antitrypsin deficiency is an inherited disorder that can cause lung disease in adults and liver disease in adults and children. Alpha-1 antitrypsin (aat) is a protein that protects the lungs. The liver usually makes the protein, and releases it into the bloodstream. Because of a gene problem, some people have little or none of it. Not having enough aat puts you at risk of emphysema or liver problems. If you smoke, you increase your risk. Children with aat deficiency can develop liver problems that last their whole lives. Aat deficiency can be treated but not cured. One treatment involves adding to or replacing the missing protein. A lung transplant may be an option if you are seriously ill. Staying away from cigarette smoke is crucial.a blood test can tell if you have the deficiency. If you have it, your family members should also take the blood test.
  • Autosomal recessive trait leading to destruction of lung tissue by neutrophil elastase and eventual emphysema; second only to cystic fibrosis as most common lethal genetic disorder among caucasians of northern european ancestry.
  • Deficiency of the protease inhibitor alpha 1-antitrypsin that manifests primarily as pulmonary emphysema and liver cirrhosis.
Applies To
  • AAT deficiency
Convert to ICD-10-CM: 273.4 converts directly to:
  • 2014 ICD-10-CM E88.01 Alpha-1-antitrypsin deficiency
ICD-9-CM Volume 2 Index entries containing back-references to 273.4:
  • AAT (alpha-1 antitrypsin) deficiency 273.4
  • Deficiency, deficient
    • AAT (alpha-1 antitrypsin) 273.4
    • alpha-1-antitrypsin 273.4
    • alpha-1-trypsin inhibitor 273.4
    • antitrypsin 273.4
    • serum
      • antitrypsin, familial 273.4
      • protein (congenital) 273.8
ICD-9-CM codes are used in medical billing and coding to describe diseases, injuries, symptoms and conditions. ICD-9-CM 273.4 is one of thousands of ICD-9-CM codes used in healthcare. Although ICD-9-CM and CPT codes are largely numeric, they differ in that CPT codes describe medical procedures and services. Can't find a code? Start at the root of ICD-9-CM, check the 2014 ICD-9-CM Index or use the search engine at the top of this page to lookup any code.