• A thickening and loss of elasticity of the walls of arteries that occurs with formation of atherosclerotic plaques within the arterial intima.
  • Age, lifestyle, diet, and gene related degeneration of arteries due to deposition of lipoid plaques (atheromas) on inner arterial walls; main cause of coronary artery disease, a leading cause of death.
  • Atherosclerosis is a disease in which plaque builds up inside your arteries. Plaque is a sticky substance made up of fat, cholesterol, calcium, and other substances found in the blood. Over time, plaque hardens and narrows your arteries. That limits the flow of oxygen-rich blood to your body and can lead to serious problems, including
    • coronary artery disease. These arteries supply blood to your heart. When they are blocked, you can suffer angina or a heart attack.
    • carotid artery disease. These arteries supply blood to your brain. When they are blocked you can suffer a stroke.
    • peripheral arterial disease. These arteries are in your arms, legs and pelvis. When they are blocked, you can suffer from numbness, pain and sometimes infections.
    atherosclerosis usually doesn't cause symptoms until it severely narrows or totally blocks an artery. Many people don't know they have the disease until they have a medical emergency.a physical examination, imaging and other diagnostic tests can tell if you have it. Treatments include medicines, and medical procedures or surgery. Lifestyle changes can also help. These include following a healthy diet, getting regular exercise, maintaining a healthy weight, quitting smoking, and managing stress.
  • Build-up of fatty material and calcium deposition in the arterial wall resulting in partial or complete occlusion of the arterial lumen.
  • Deposition of cholesterol and lipid in the inner layer of the blood vessel