
Aplastic anemia

Constitutional aplastic anemia
- familial or idiopathic form, usually fatal; Fanconi's anemia presents before age 10, marked by microcephaly, skin discolorations, and sexual and mental retardation.

Constitutional red blood cell aplasia
- familial or idiopathic form, usually fatal; Fanconi's anemia presents before age 10, marked by microcephaly, skin discolorations, and sexual and mental retardation.

Other constitutional aplastic anemia
- A rare and often fatal inherited disease in which the bone marrow fails to produce red blood cells, white blood cells, platelets, or a combination of these cells. The disease may transform into myelodysplastic syndrome or leukemia.
- Fanconi anemia (FA) is an autosomal recessive genetic disorder characterised clinically by progressive bone marrow failure, skeletal deformities and a predisposition to neoplasia. Patient cells manifest an extreme chromosomal instability and hypersensitivity to polyfunctional alkylating agents. It is assumed that the basic defect is related to the repair of DNA damage, in particular that of so-called DNA crosslinks. Currently there are eight complementation groups in FA (FA-A-FA-H) which indicates that at least eight independent genes can lead to FA. Three of these genes have been identified: FANCA, FANCC and FANCG. (from PMID 10472548)

Pancytopenia

Myelophthisis

Other specified aplastic anemias

Other specified aplastic anemias

Red cell aplasia (acquired)(adult) (with thymoma)

Aplastic anemia unspecified
- anemia associated with a fatty, hypocellular bone marrow and global dyshematopoiesis; can be idiopathic or due to microbial, metabolic, autoimmune, or other abnormality.
- A condition in which the bone marrow is unable to produce blood cells.
- Anemia resulting from bone marrow failure (aplastic or hypoplastic bone marrow). The production of erythroblasts and red cells is markedly decreased, and it may be associated with decreased production of granulocytes (granulocytopenia) and platelets (thrombocytopenia) as well. Aplastic anemia may be idiopathic or secondary due to bone marrow damage by toxins, radiation, or immunologic factors. -- 2004