chronic leukemia in which myeloid progenitor cells predominate; the hallmark of CML, the Philadelphia chromosome, is a reciprocal translocation between chromosomes 9 and 22 which activates the proto- oncogene c-abl.
A slowly progressing disease in which too many white blood cells are made in the bone marrow.
The most common chronic myeloproliferative disorder characterized by neutrophilic leukocytosis. It is associated with the Philadelphia (Ph) chromosome and/or the BCR/ABL fusion gene. Most patients are middle-aged or elderly. Common findings at presentation include fatigue, weight loss, anemia, night sweats, and splenomegaly. The disease is bi- or triphasic; an initial indolent chronic phase is followed by an accelerated or blast phase. Allogeneic bone marrow transplantation is currently the only curative therapy (adapted from WHO 2001).
Also applicable to/known as
Eosinophilic leukemia
Neutrophilic leukemia
ICD-9-CM Volume 2 Index Entries That Refer To 205.1
2009 ICD-9-CM Diagnosis Code 205.1
205.1
