2008 ICD-9-CM Volume 1 Diagnosis Codes Home > Infectious And Parasitic Diseases 001-139 > Poliomyelitis And Other Non-Arthropod-Borne Viral Diseases Of Central Nervous System 045-049 > Slow Virus Infection Of Central Nervous System 046.* >  2008 ICD-9-CM Diagnosis 046.3
Progressive multifocal leukoencephalopathy- An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)
- 046.3 is a specific code that can be used to specify a diagnosis
- 046.3 contains 2 index entries
- View the ICD-9-CM Volume 1 046.* hierarchy
046.3 also known as:- Multifocal leukoencephalopathy NOS
Index entries containing 046.3:- Leukoencephalopathy (see also Encephalitis) 323.9
- multifocal (progressive)
 046.3
- progressive multifocal 046.3
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