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2007 ICD-9-CM Volume 1 Diagnosis Codes Home > Diseases Of The Nervous System And Sense Organs 320-389 > Hereditary And Degenerative Diseases Of The Central Nervous System 330-338 > Other Extrapyramidal Disease And Abnormal Movement Disorders 333.* > 2007 ICD-9-CM Diagnosis 333.92 Neuroleptic malignant syndrome This code may be outdated. View the most recent version of ICD-9-CM 333.92 A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72) 333.92 is a specific code that can be used to specify a diagnosis 333.92 contains 2 index entries View the ICD-9-CM Volume 1 333.* hierarchy Use additional E to identify drug 333.92 excludes: neuroleptic induced Parkinsonism (332.1) Index entries containing 333.92: Neuroleptic malignant syndrome 333.92 Syndrome - see also Disease neuroleptic malignant 333.92