Specific code 2015 ICD-9-CM Diagnosis Code 333.92
Neuroleptic malignant syndrome
  • 2015
  • Billable Thru Sept 30/2015
  • Non-Billable On/After Oct 1/2015

  • ICD-9-CM 333.92 is a billable medical code that can be used to indicate a diagnosis on a reimbursement claim, however, 333.92 should only be used for claims with a date of service on or before September 30, 2015. For claims with a date of service on or after October 1, 2015, use an equivalent ICD-10-CM code (or codes).
Convert to ICD-10-CM: 333.92 converts directly to:
  • 2015/16 ICD-10-CM G21.0 Malignant neuroleptic syndrome
Clinical Information
  • A life-threatening condition that may be caused by certain drugs used to treat mental illness, nausea, or vomiting. Symptoms include high fever, sweating, unstable blood pressure, confusion, and stiffness
  • A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see antipsychotic agents) which are in turn associated with dopaminergic receptor blockade (see receptors, dopamine) in the basal ganglia and hypothalamus, and sympathetic dysregulation. Clinical features include diffuse muscle rigidity; tremor; high fever; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum cpk level elevation and a leukocytosis may also be present. (from Adams et al., Principles of Neurology, 6th ed, p1199; psychiatr serv 1998 sep;49(9):1163-72)
  • A rare, life-threatening disorder that is caused by neuroleptic medications. It is characterized by fever, muscular cramps and rigidity, autonomic nervous system dysfunction, and changes in the mental status that may lead to coma
333.92 Excludes
  • neuroleptic induced Parkinsonism (332.1)
Use Additional
  • Use additional E to identify drug
ICD-9-CM Volume 2 Index entries containing back-references to 333.92:
  • Neuroleptic malignant syndrome 333.92
  • Syndrome - see also Disease
    • neuroleptic malignant 333.92
ICD-9-CM codes are used in medical billing and coding to describe diseases, injuries, symptoms and conditions. ICD-9-CM 333.92 is one of thousands of ICD-9-CM codes used in healthcare. Although ICD-9-CM and CPT codes are largely numeric, they differ in that CPT codes describe medical procedures and services. Can't find a code? Start at the root of ICD-9-CM, check the 2015 ICD-9-CM Index or use the search engine at the top of this page to lookup any code.