- A congenital hemolytic anemia caused by defects of the erythrocyte membrane, enzyme deficiencies, or hemoglobinopathies.
- A familial congenital hemolytic anemia characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. The erythrocytes have increased osmotic fragility and are abnormally permeable to sodium ions.
- An autosomal dominant inherited disorder characterized by the presence of smaller than normal, sphere-shaped erythrocytes. It results in hemolytic anemia and splenomegaly.
- Autosomal dominant trait marked by splenomegaly, jaundice, and fragile, spheroid erythrocytes which are prematurely cleared by the spleen; anemia is usually mild; treatment is splenectomy.
- Hemolytic anemia due to various intrinsic defects of the erythrocyte.
- Includes hereditary erythrocyte membrane defects, enzyme deficiencies, hemoglobin abnormalities, stem cell defects (paroxysmal nocturnal hemoglobinuria), and alloimmune (rh) disease of newborn.
282 Hereditary hemolytic anemias 
282.0 Hereditary spherocytosis convert 282.0 to ICD-10-CM
