
Hereditary hemolytic anemias
- includes hereditary erythrocyte membrane defects, enzyme deficiencies, hemoglobin abnormalities, stem cell defects (paroxysmal nocturnal hemoglobinuria), and alloimmune (Rh) disease of newborn.

Hereditary spherocytosis
- includes hereditary erythrocyte membrane defects, enzyme deficiencies, hemoglobin abnormalities, stem cell defects (paroxysmal nocturnal hemoglobinuria), and alloimmune (Rh) disease of newborn.
- autosomal dominant trait marked by splenomegaly, jaundice, and fragile, spheroid erythrocytes which are prematurely cleared by the spleen; anemia is usually mild; treatment is splenectomy.

Hereditary elliptocytosis
- intrinsic defect of erythrocytes inherited as an autosomal dominant trait; erythrocytes assume an oval or elliptical shape.

Anemias due to disorders of glutathione metabolism

Other hemolytic anemias due to enzyme deficiency

Thalassemias
- heterogeneous group of hereditary hemolytic anemias which have in common a decreased rate of synthesis of one or more hemoglobin polypeptide chains.

Sickle-cell thalassemia without crisis

Sickle-cell thalassemia with crisis

Other thalassemia
- heterogeneous group of hereditary hemolytic anemias which have in common a decreased rate of synthesis of one or more hemoglobin polypeptide chains.

Sickle-cell trait

Sickle-cell disease
- disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs; the clinical expression of homozygosity for hemoglobin S.

Sickle-cell disease unspecified
- disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs; the clinical expression of homozygosity for hemoglobin S.

Hb-ss disease without crisis

Hb-ss disease with crisis
- broad term used to describe several different acute conditions occurring with sickle cell disease, including aplastic crisis, hemolytic crisis, and vasoocclusive crisis.

Sickle-cell/hb-c disease without crisis

Sickle-cell/hb c disease with crisis

Other sickle-cell disease without crisis

Other sickle-cell disease with crisis

Other hemoglobinopathies
- group of inherited disorders characterized by structural alterations within the hemoglobin molecule.

Other specified hereditary hemolytic anemias

Hereditary hemolytic anemia unspecified
- includes hereditary erythrocyte membrane defects, enzyme deficiencies, hemoglobin abnormalities, stem cell defects (paroxysmal nocturnal hemoglobinuria), and alloimmune (Rh) disease of newborn.