includes hereditary erythrocyte membrane defects, enzyme deficiencies, hemoglobin abnormalities, stem cell defects (paroxysmal nocturnal hemoglobinuria), and alloimmune (Rh) disease of newborn.
autosomal dominant trait marked by splenomegaly, jaundice, and fragile, spheroid erythrocytes which are prematurely cleared by the spleen; anemia is usually mild; treatment is splenectomy.