2015 ICD-9-CM Diagnosis Code 335.2
Motor neuron disease
- There are 6 ICD-9-CM codes below 335.2 that define this diagnosis in greater detail. Do not use this code on a reimbursement claim.
Clinical Information
- A degenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, fasciculation, hyperreflexia, dysarthria, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous astrocytes and atrophy of anterior spinal nerve roots and corticospinal tracts. (from Adams et al., Principles of Neurology, 6th ed, pp1089-94)
- Amyotrophic lateral sclerosis (als) is a nervous system disease that attacks nerve cells called neurons in your brain and spinal cord. These neurons transmit messages from your brain and spinal cord to your voluntary muscles - the ones you can control, like in your arms and legs. At first, this causes mild muscle problems. Some people notice
- trouble walking or running
- trouble writing
- speech problems
eventually, you lose your strength and cannot move. When muscles in your chest fail, you cannot breathe. A ventilator can help, but most people with als die from respiratory failure. The disease usually strikes between age 40 and 60. More men than women get it. No one knows what causes als. It can run in families, but usually it strikes at random. There is no cure. Medicines can relieve symptoms and, sometimes, prolong survival - An autosomal dominant inherited form of amyloidosis
- Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In amyotrophic lateral sclerosis there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see muscular atrophy, spinal) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (bulbar palsy, progressive), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)
- Disorders of motor neurons which result in atrophy, fasciculation and fibrillations, spasticity, decreased muscle tone, loss of or overactive tendon reflexes, and abnormal extensor reflexes
- Progressive degeneration of the neurons that give rise to the corticospinal tract and of the motor cells of the brain stem and spinal cord, resulting in a deficit of upper and lower motor neurons
