ICD-9-CM 331.81 is a billable medical code that can be used to indicate a diagnosis on a reimbursement claim, however, 331.81 should only be used for claims with a date of service on or before September 30, 2015. For claims with a date of service on or after October 1, 2015, use an equivalent ICD-10-CM code (or codes).
A form of encephalopathy with fatty infiltration of the liver, characterized by brain edema and vomiting that may rapidly progress to seizures; coma; and death. It is caused by a generalized loss of mitochondrial function leading to disturbances in fatty acid and carnitine metabolism
A rare disease that damages the brain and liver and causes death if not treated. It occurs most often in children younger than 15 years who have had a fever-causing virus, such as chickenpox or flu. Taking aspirin during a viral illness may increase the risk of reye syndrome
An acute and potentially fatal metabolic disorder characterized by cerebral edema, fatty liver and hypoglycemia. It occurs primarily in children and has been associated with the use of aspirin for the treatment of viral infections. However, it can also occur in the absence of aspirin use
Rare, acute, sometimes fatal disease of childhood, most often occurring as a sequel of varicella or a viral upper respiratory infection of childhood; marked by recurrent vomiting and elevated serum transaminase levels with distinctive changes in the liver and other viscera; an encephalopathic phase with acute brain swelling disturbances of consciousness and seizures may follow
Reye syndrome is a rare illness that can affect the blood, liver and brain of someone who recently had a viral infection. It always follows another illness. Although it mostly affects children and teens, anyone can get it. It can develop quickly and without warning. It is most common during flu season. Symptoms include
nausea and vomiting
listlessness
personality change - such as irritability, combativeness or confusion
delirium
convulsions
loss of consciousness
if these symptoms occur soon after a viral illness, seek medical attention immediately. Reye syndrome can lead to a coma and brain death, so quick diagnosis and treatment are critical. Treatment focuses on preventing brain damage. There is no cure.the cause of reye syndrome is unknown. However, studies have shown that taking aspirin increases the risk of getting it. Because of that, health care professionals now recommend other pain relievers for young patients
ICD-9-CM Coding Information
331.81 is only applicable to pediatric patients aged 0 - 17 years inclusive.
2015 ICD-9-CM Diagnosis Code 331.81 
Reye's 331.81
