Specific code 2014 ICD-9-CM Diagnosis Code 288.4
Hemophagocytic syndromes
  • Billable Code
  • ICD-9-CM 288.4 will be replaced by an equivalent ICD-10-CM code (or codes) when the United States transitions from ICD-9-CM to ICD-10-CM on October 1, 2015.
  • ICD-9-CM 288.4 is a billable medical code that can be used to specify a diagnosis on a reimbursement claim.
Disease Synonyms
  • Familial hemophagocytic lymphohistiocytosis
  • Hemophagocytic lymphohistiocytosis
  • Hemophagocytic syndrome
  • Hemophagocytic syndrome, infection-associated
  • Infection w hemophagocytic syndrome
Clinical Information
  • A group of related disorders characterized by lymphocytosis; histiocytosis; and hemophagocytosis. The two major forms are familial and reactive.
  • A rare but potentially life-threatening disorder characterized by the proliferation of histiocytes and macrophages and phagocytosis of red blood cells, white blood cells, and platelets. It may be inherited or secondary, due to infections, autoimmune disorders, or underlying malignancies. Signs and symptoms include fever, lymphadenopathy, hepatomegaly, splenomegaly, and pancytopenia.
  • A rare disorder in which histiocytes and lymphocytes (types of white blood cells) build up in organs including the skin, spleen, and liver, and destroy other blood cells. Hemophagocytic lymphohistiocytosis may be inherited or caused by certain conditions or diseases, including infections, immunodeficiency (inability of the body to fight infections), and cancer.
Applies To
  • Familial hemophagocytic lymphohistiocytosis
  • Familial hemophagocytic reticulosis
  • Hemophagocytic syndrome, infection-associated
  • Histiocytic syndromes
  • Macrophage activation syndrome
Convert to ICD-10-CM: 288.4 converts approximately to:
  • 2014 ICD-10-CM D76.1 Hemophagocytic lymphohistiocytosis
    Or:
  • 2014 ICD-10-CM D76.2 Hemophagocytic syndrome, infection-associated
    Or:
  • 2014 ICD-10-CM D76.3 Other histiocytosis syndromes
ICD-9-CM Volume 2 Index entries containing back-references to 288.4:
  • Family, familial - see also condition
    • hemophagocytic
      • lymphohistiocytosis 288.4
      • reticulosis 288.4
  • Hemophagocytic syndrome 288.4
    • infection-associated 288.4
  • Histiocytic syndromes 288.4
  • Lymphohistiocytosis, familial hemophagocytic 288.4
  • Macrophage activation syndrome 288.4
  • Reticulosis (skin)
    • familial hemophagocytic 288.4
  • Syndrome - see also Disease
    • hemophagocytic 288.4
      • infection-associated 288.4
    • histiocytic 288.4
    • macrophage activation 288.4
ICD-9-CM codes are used in medical billing and coding to describe diseases, injuries, symptoms and conditions. ICD-9-CM 288.4 is one of thousands of ICD-9-CM codes used in healthcare. Although ICD-9-CM and CPT codes are largely numeric, they differ in that CPT codes describe medical procedures and services. Can't find a code? Start at the root of ICD-9-CM, check the 2014 ICD-9-CM Index or use the search engine at the top of this page to lookup any code.