Specific code 2014 ICD-9-CM Diagnosis Code 288.2
Genetic anomalies of leukocytes
  • Billable Code
  • Short description: Genetic anomaly leukocyt.
  • ICD-9-CM 288.2 will be replaced by an equivalent ICD-10-CM code (or codes) when the United States transitions from ICD-9-CM to ICD-10-CM on October 1, 2015.
  • ICD-9-CM 288.2 is a billable medical code that can be used to specify a diagnosis on a reimbursement claim.
Disease Synonyms
  • Alder syndrome
  • Alders syndrome
  • Chediak Higashi syndrome
  • Chédiak-Higashi syndrome
  • Genetic anomaly of leukocyte
  • Genetic leukocyte disorder
  • Hereditary giant neutrophilia
  • Hereditary hypersegmentation
  • Hypersegmentation
  • Hypersegmentation, hereditary
  • Leukocyte adhesion deficiency - type 1
  • Leukocyte adhesion deficiency - type 2
  • Leukocyte adhesion deficiency type 1
  • Leukocyte adhesion deficiency type 2
  • Leukocyte disorder, genetic
  • May Hegglin anomaly
  • May-Hegglin anomaly
  • Pelger Huet anomaly
  • Pelger-Huet anomaly
  • Pelger-Huët anomaly
Clinical Information
  • A rare autosomal recessive immunodeficiency disorder characterized by abnormal intracellular protein transport. Chediak-higashi syndrome (chs) is characterized by immune deficiency; partial oculocutaneous albinism; a bleeding disorder due to deficient platelet dense bodies; neutropenia; neutrophils with impaired chemotaxis and bactericidal activity; recurrent infection; and abnormal natural killer (nk) cell function. Chs may be associated with hepatosplenomegaly, lymphadenopathy, anemia, thrombocytopenia, roentgenologic changes in bones, lungs and heart, and skin and psychomotor abnormalities; it is often fatal in childhood as a result of infection or an accelerated lymphoma-like phase. Chs occurs in mink, cattle, and mice, as well as man.
  • Form of phagocyte bactericidal dysfunction characterized by unusual oculocutaneous albinism, high incidence of lymphoreticular neoplasms, and recurrent pyogenic infections; in many cell types, abnormal lysosomes are present leading to defective pigment distribution and abnormal neutrophil functions; transmitted by autosomal recessive inheritance and a similar disorder occurs in the beige mouse, the aleutian mink, and albino hereford cattle.
Applies To
  • Anomaly (granulation) (granulocyte) or syndrome:
    • Alder's (-Reilly)
    • Chédiak-Steinbrinck (-Higashi)
    • Jordan's
    • May-Hegglin
    • Pelger-Huet
  • Hereditary:
    • hypersegmentation
    • hyposegmentation
    • leukomelanopathy
Convert to ICD-10-CM: 288.2 converts directly to:
  • 2014 ICD-10-CM D72.0 Genetic anomalies of leukocytes
ICD-9-CM Volume 2 Index entries containing back-references to 288.2:
  • Alder's anomaly or syndrome (leukocyte granulation anomaly) 288.2
  • Alder-Reilly anomaly (leukocyte granulation) 288.2
  • Anomaly, anomalous (congenital) (unspecified type) 759.9
    • Alder (-Reilly) (leukocyte granulation) 288.2
    • Chédiak-Higashi (-Steinbrinck) (congenital gigantism of peroxidase granules) 288.2
    • granulation or granulocyte, genetic 288.2
      • constitutional 288.2
      • leukocyte 288.2
    • Hegglin's 288.2
    • hypersegmentation of neutrophils, hereditary 288.2
    • Jordan's 288.2
    • leukocytes, genetic 288.2
      • granulation (constitutional) 288.2
    • May (-Hegglin) 288.2
    • pelger-Huët (hereditary hyposegmentation) 288.2
  • Chédiak-Higashi (-Steinbrinck) anomaly, disease, or syndrome (congenital gigantism of peroxidase granules) 288.2
  • Disease, diseased - see also Syndrome
    • Chédiak-Steinbrinck (-Higashi) (congenital gigantism of peroxidase granules) 288.2
  • Döhle body-panmyelopathic syndrome 288.2
  • Hegglin's anomaly or syndrome 288.2
  • Hypersegmentation, hereditary 288.2
    • eosinophils 288.2
    • neutrophil nuclei 288.2
  • Hyposegmentation of neutrophils, hereditary 288.2
  • Inclusion
    • azurophilic leukocytic 288.2
  • Jordan's anomaly or syndrome 288.2
  • Leukomelanopathy, hereditary 288.2
  • May (-Hegglin) anomaly or syndrome 288.2
  • Neutrophilia, hereditary giant 288.2
  • Pelger-Huët anomaly or syndrome (hereditary hyposegmentation) 288.2
  • Phenomenon
    • Pelger-Huët (hereditary hyposegmentation) 288.2
  • Syndrome - see also Disease
    • Alder's (leukocyte granulation anomaly) 288.2
    • Béquez César (-Steinbrinck-Chédiak-Higashi) (congenital gigantism of peroxidase granules) 288.2
    • Chédiak-Higashi (-Steinbrinck) (congenital gigantism of peroxidase granules) 288.2
    • Döhle body-panmyelopathic 288.2
    • Hegglin's 288.2
    • Jordan's 288.2
    • May (-Hegglin) 288.2
    • Pelger-Huët (hereditary hyposegmentation) 288.2
ICD-9-CM codes are used in medical billing and coding to describe diseases, injuries, symptoms and conditions. ICD-9-CM 288.2 is one of thousands of ICD-9-CM codes used in healthcare. Although ICD-9-CM and CPT codes are largely numeric, they differ in that CPT codes describe medical procedures and services. Can't find a code? Start at the root of ICD-9-CM, check the 2014 ICD-9-CM Index or use the search engine at the top of this page to lookup any code.