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2008 ICD-9-CM Volume 1 Diagnosis Codes Home > Diseases Of The Blood And Blood-Forming Organs 280-289 > ICD-9-CM Diagnosis 284 Aplastic anemia A condition in which the bone marrow is unable to produce blood cells. A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. Anemia resulting from bone marrow failure (aplastic or hypoplastic bone marrow). The production of erythroblasts and red cells is markedly decreased, and it may be associated with decreased production of granulocytes (granulocytopenia) and platelets (thrombocytopenia) as well. Aplastic anemia may be idiopathic or secondary due to bone marrow damage by toxins, radiation, or immunologic factors. -- 2004 284 is a non-specific code that cannot be used to specify a diagnosis ICD-9-CM Diagnosis 284.0 Constitutional aplastic anemia A rare and often fatal inherited disease in which the bone marrow fails to produce red blood cells, white blood cells, platelets, or a combination of these cells. The disease may transform into myelodysplastic syndrome or leukemia. A rare congenital hypoplastic anemia that usually presents early in infancy. The disease is characterized by a moderate to severe macrocytic anemia, occasional neutropenia or thrombocytosis, a normocellular bone marrow with erythroid hypoplasia, and an increased risk of developing leukemia. (Curr Opin Hematol 2000 Mar;7(2):85-94) An inborn condition characterized by deficiencies of red cell precursors that sometimes also includes LEUKOPENIA and THROMBOCYTOPENIA. Congenital disorder affecting all bone marrow elements, resulting in anemia, leukopenia, and thrombopenia, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous chromosome breakage is a feature of this disease along with predisposition to leukemia. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD, FANCE, FANCF, FANCG. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/Omim, MIM# 227650, April 23, 2001) Fanconi anemia (FA) is an autosomal recessive genetic disorder characterised clinically by progressive bone marrow failure, skeletal deformities and a predisposition to neoplasia. Patient cells manifest an extreme chromosomal instability and hypersensitivity to polyfunctional alkylating agents. It is assumed that the basic defect is related to the repair of DNA damage, in particular that of so-called DNA crosslinks. Currently there are eight complementation groups in FA (FA-A-FA-H) which indicates that at least eight independent genes can lead to FA. Three of these genes have been identified: FANCA, FANCC and FANCG. (from PMID 10472548) Suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production. 284.0 is a non-specific code that cannot be used to specify a diagnosis ICD-9-CM Diagnosis 284.01 Constitutional red blood cell aplasia 284.01 is a specific code that can be used to specify a diagnosis 284.01 contains 35 index entries ICD-9-CM Diagnosis 284.09 Other constitutional aplastic anemia 284.09 is a specific code that can be used to specify a diagnosis 284.09 contains 18 index entries ICD-9-CM Diagnosis 284.1 Pancytopenia 284.1 is a specific code that can be used to specify a diagnosis 284.1 contains 1 index entry ICD-9-CM Diagnosis 284.2 Myelophthisis 284.2 is a specific code that can be used to specify a diagnosis 284.2 contains 6 index entries ICD-9-CM Diagnosis 284.8 Other specified aplastic anemias Deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets. Suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production. 284.8 is a non-specific code that cannot be used to specify a diagnosis ICD-9-CM Diagnosis 284.81 Other specified aplastic anemias 284.81 is a specific code that can be used to specify a diagnosis 284.81 contains 12 index entries ICD-9-CM Diagnosis 284.89 Red cell aplasia (acquired)(adult) (with thymoma) 284.89 is a specific code that can be used to specify a diagnosis 284.89 contains 13 index entries ICD-9-CM Diagnosis 284.9 Aplastic anemia unspecified A condition in which the bone marrow is unable to produce blood cells. A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. A severe sometimes chronic anemia, usually macrocytic in type, that does not respond to ordinary antianemic therapy. Anemia resulting from bone marrow failure (aplastic or hypoplastic bone marrow). The production of erythroblasts and red cells is markedly decreased, and it may be associated with decreased production of granulocytes (granulocytopenia) and platelets (thrombocytopenia) as well. Aplastic anemia may be idiopathic or secondary due to bone marrow damage by toxins, radiation, or immunologic factors. -- 2004 284.9 is a specific code that can be used to specify a diagnosis 284.9 contains 27 index entries