• A diverse group of lesions characterized by excessive proliferation of trophoblasts. These include premalignant lesions: hydatidiform mole (complete and partial) and malignant disorders: invasive mole, choriocarcinoma, placental site trophoblastic tumor and miscellaneous trophoblastic lesions. These tumors are very chemosensitive. All produce human chorionic gonadotrophin which is utilized as a tumor marker.
  • A gestational disorder characterized by an abnormal placenta with marked enlargement of the chorionic villi and hyperplasia of the villous trophoblastic cells. According to the amount of villous involvement, a hydatidiform mole is defined as complete or partial. Most molar pregnancies are complete and are characterized by generalized hydropic villous changes. Partial moles are characterized by a mixture of large hydropic villi and normal placenta tissue. Complete moles are usually diploid and typically present between the eleventh and twenty-fifth week of pregnancy, whereas partial moles are usually triploid and usually present around the nineteenth week of pregnancy. The incidence of choriocarcinoma is higher in patients with complete hydatidiform mole. When a hydatidiform mole invades the myometrium and broad ligament, or it is found in distant sites as vagina, vulva, and lung, it is referred as invasive mole.
  • A rare cancer in women of childbearing age in which cancer cells grow in the tissues that are formed in the uterus after conception.
  • A rare cancer in women of childbearing age in which cancer cells grow in the tissues that are formed in the uterus after conception. Also called gestational trophoblastic disease, gestational trophoblastic neoplasia, gestational trophoblastic tumor, or choriocarcinoma.
  • A slow-growing tumor that develops from trophoblastic cells (cells that help an embryo attach to the uterus and help form the placenta) after fertilization of an egg by a sperm. A hydatidiform mole contains many cysts (sacs of fluid). It is usually benign (not cancer) but it may spread to nearby tissues (invasive mole). It may also become a malignant tumor called choriocarcinoma. Hydatidiform mole is the most common type of gestational trophoblastic tumor.
  • Trophoblastic hyperplasia associated with normal gestation, or molar pregnancy. It is characterized by the swelling of the chorionic villi and elevated human chorionic gonadotropin. Hydatidiform moles or molar pregnancy may be categorized as complete or partial based on their gross morphology, histopathology, and karyotype.
  • Trophoblastic hyperplasia associated with normal gestation, or molar pregnancy; characterized by the swelling of the chorionic villi and elevated human chorionic gonadotropin; hydatidiform moles or molar pregnancy may be categorized as complete or partial based on their gross morphology, histopathology, and karyotype.