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2007 ICD-9-CM Volume 1 Diagnosis Codes Home > Diseases Of Blood And Blood-Forming Organs 280-289 > Other Diseases Of Blood And Blood-Forming Organs 289.* > 2007 ICD-9-CM Diagnosis 289.81 Primary hypercoagulable state  On October 1, 2008 the 2009 ICD-9-CM codes came into effect. Therefore, this code may be out of date. The 2009 version of ICD-9-CM 289.81 can be accessed here. A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance. An absence or deficiency in PROTEIN C which leads to impaired regulation of blood coagulation. It is associated with an increased risk of severe or premature thrombosis. (Stedman's Med. Dict., 26th ed.) An absence or reduced level of Antithrombin III leading to an increased risk for thrombosis. An autosomal dominant disorder showing decreased levels of plasma protein S antigen or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein C deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (From Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology, 9th ed, p1523) 289.81 is a specific code that can be used to specify a diagnosis 289.81 contains 9 index entries View the ICD-9-CM Volume 1 289.* hierarchy 289.81 also known as: Activated protein C resistance Antithrombin III deficiency Factor V Leiden mutation Lupus anticoagulant Protein C deficiency Protein S deficiency Prothrombin gene mutation Index entries containing 289.81: Deficiency, deficient antithrombin III 289.81 protein 260 C 289.81 S 289.81 Hypercoagulation syndrome (primary) 289.81 secondary 289.82 Lupus 710.0 anticoagulant 289.81 Mutation factor V leiden 289.81 prothrombin gene 289.81 Resistance, resistant (to) activated protein C 289.81 State hypercoagulable (primary) 289.81 secondary 289.82