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2007 ICD-9-CM Volume 1 Diagnosis Codes Home > Endocrine, Nutritional And Metabolic Diseases, And Immunity Disorders 240-279 > Diseases Of Other Endocrine Glands 250-259 > Other Endocrine Disorders 259.* > 2007 ICD-9-CM Diagnosis 259.8 Other specified endocrine disorders This code may be outdated. View the most recent version of ICD-9-CM 259.8 An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature greying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA. An autosomal recessive disorder that causes premature aging in adults, characterized by sclerodermal skin changes, cataracts, subcutaneous calcification, muscular atrophy, a tendency to diabetes mellitus, aged appearance of the face, baldness, and a high incidence of neoplastic disease. Werner Syndrome (WS) is an inherited disease characterized by an early onset of atherosclerosis, osteoporosis, diabetes mellitus, and cancers of non-epithelial cell origin. Cultured cells from WS patients also present a shortened replicative lifespan and increased genetic instability. The genomic instability of WS cells is manifested at the cytogenetic level in the form of chromosome breaks and translocations, and at the molecular level predominately by multiple, large DNA deletions. (J. Biol. Chem., 273(51):34139-34144, 1998) 259.8 is a specific code that can be used to specify a diagnosis 259.8 contains 42 index entries View the ICD-9-CM Volume 1 259.* hierarchy 259.8 also known as: Pineal gland dysfunction Progeria Werner's syndrome Index entries containing 259.8: Abscess (acute) (chronic) (infectional) (lymphangitic) (metastatic) (multiple) (pyogenic) (septic) (with lymphangitis) (see also Cellulitis) 682.9 ductless gland 259.8 Calcification pineal gland 259.8 Cyst (mucus) (retention) (serous) (simple) epiphysis cerebri 259.8 Degeneration, degenerative pineal gland 259.8 Diabetes, diabetic (brittle) (congenital) (familial) (mellitus) (poorly controlled) (severe) (slight) (without complication) 250.0 glycogenosis, secondary 250.8 [259.8] Disease, diseased - see also Syndrome carotid gland 259.8 endocrine glands or system NEC 259.9 specified NEC 259.8 Gilford (-Hutchinson) (progeria) 259.8 Hutchinson-Gilford (progeria) 259.8 pineal gland 259.8 Werner's (progeria adultorum) 259.8 Disorder - see also Disease endocrine 259.9 specified type NEC 259.8 Donohue's syndrome (leprechaunism) 259.8 Dysfunction pineal gland 259.8 Gilford (-Hutchinson) disease or syndrome (progeria) 259.8 Glycogenosis (see also Disease, glycogen storage) 271.0 diabetic, secondary 250.8 [259.8] Hutchinson-Gilford disease or syndrome (progeria) 259.8 Hyperpinealism 259.8 Hypopinealism 259.8 Leprechaunism 259.8 Pellizzi's syndrome (pineal) 259.8 Perversion, perverted function pineal gland 259.8 Premature - see also condition senility (syndrome) 259.8 Presenile - see also condition aging 259.8 Presenility 259.8 Progeria (adultorum) (syndrome) 259.8 Puberty V21.1 precocious (constitutional) (cryptogenic) (idiopathic) NEC 259.1 due to pineal tumor 259.8 premature 259.1 due to pineal tumor 259.8 Senile (see also condition) 797 syndrome 259.8 Senility 797 premature (syndrome) 259.8 Syndrome - see also Disease Donohue's (leprechaunism) 259.8 Gilford (-Hutchinson) (progeria) 259.8 Hutchinson-Gilford (progeria) 259.8 macrogenitosomia praecox 259.8 Pellizzi's (pineal) 259.8 pineal 259.8 premature senility 259.8 progeria 259.8 senilism 259.8 trigeminal plate 259.8 Werner's (progeria adultorum) 259.8 Werner's disease or syndrome (progeria adultorum) 259.8