Multiple myeloma and immunoproliferative neoplasms
Multiple myeloma
- malignant neoplasm of plasma cells usually arising in the bone marrow and manifested by skeletal destruction, bone pain, and the presence of anomalous immunoglobulins.
- (mye-eh-LO-ma) Cancer that arises in plasma cells (white blood cells that produce antibodies).
- A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. (WHO, 2001)
Multiple myeloma without remission
Multiple myeloma in remission
Plasma cell leukemia
- rare type of acute leukemia in which the predominating cell in the peripheral blood is the plasma cell; it is often seen in conjunction with multiple myeloma and may be a variant form of that disease.
- An aggressive plasma cell neoplasm with usually short survival. It is characterized by the presence of neoplastic plasma cells in the peripheral blood. The peripheral blood plasma cells comprise more than 20% of the peripheral blood white cells. It may be the initial presentation of a plasma cell neoplasm or manifest as a terminal complication of plasma cell myeloma. Lymphadenopathy and organomegaly are frequent clinical signs, whereas bone pain and osteolytic lesions are less frequently present.
Plasma cell leukemia without remission
Plasma cell leukemia in remission
- History of plasmacytic leukemia after therapy with no evidence on the peripheral blood or bone marrow of leukemia (normalization of all hematologic parameters).
Other immunoproliferative neoplasms
Other immunoproliferative neoplasms without remission
Other immunoproliferative neoplasms in remission
