2006 ICD-9-CM Volume 1 Diagnosis Codes Home > Diseases Of The Nervous System And Sense Organs 320-389 > Hereditary And Degenerative Diseases Of The Central Nervous System 330-338 > Cerebral Degenerations Usually Manifest In Childhood 330.* > 2006 ICD-9-CM Diagnosis 330.8 Other specified cerebral degenerations in childhood View the most recent version of ICD-9-CM 330.8 A group of metabolic disorders primarily of infancy characterized by the subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, dysphagia, and lactic acidosis. Pathological features include spongy degeneration of the neuropile of the basal ganglia, thalamus, brain stem, and spinal cord. Patterns of inheritance include X-linked recessive, autosomal recessive, and mitochondrial. Leigh disease has been associated with mutations in genes for the PYRUVATE DEHYDROGENASE COMPLEX; CYTOCHROME-C OXIDASE; ATP synthase subunit 6; and subunits of mitochondrial complex I. (From Menkes, Textbook of Child Neurology, 5th ed, p850). 330.8 is a specific code that can be used to specify a diagnosis 330.8 contains 12 index entries View the ICD-9-CM Volume 1 330.* hierarchy Alternate Terminology Alpers' disease or gray-matter degeneration Infantile necrotizing encephalomyelopathy Leigh's disease Subacute necrotizing encephalopathy or encephalomyelopathy  Index entries containing 330.8: Alpers' disease 330.8 Degeneration, degenerative brain (cortical) (progressive) 331.9 childhood 330.9 specified type NEC 330.8 grey matter 330.8 grey matter 330.8 Disease, diseased - see also Syndrome Alpers' 330.8 Leigh's 330.8 Encephalomyelopathy 349.9 subacute necrotizing (infantile) 330.8 Encephalopathy (acute) 348.30 necrotizing subacute 330.8 subacute necrotizing 330.8 Leigh's disease 330.8 Rett's syndrome 330.8 Syndrome - see also Disease Rett's 330.8