2006 ICD-9-CM Volume 1 Diagnosis Codes Home > Diseases Of Blood And Blood-Forming Organs 280-289 > ICD-9-CM Diagnosis 284 Aplastic anemia A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. Anemia resulting from bone marrow failure (aplastic or hypoplastic bone marrow). The production of erythroblasts and red cells is markedly decreased, and it may be associated with decreased production of granulocytes (granulocytopenia) and platelets (thrombocytopenia) as well. Aplastic anemia may be idiopathic or secondary due to bone marrow damage by toxins, radiation, or immunologic factors. -- 2004 A condition in which the bone marrow is unable to produce blood cells. 284 is a non-specific code that cannot be used to specify a diagnosis ICD-9-CM Diagnosis 284.0 Constitutional aplastic anemia Suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production. An inborn condition characterized by deficiencies of red cell precursors that sometimes also includes LEUKOPENIA and THROMBOCYTOPENIA. A rare congenital hypoplastic anemia that usually presents early in infancy. The disease is characterized by a moderate to severe macrocytic anemia, occasional neutropenia or thrombocytosis, a normocellular bone marrow with erythroid hypoplasia, and an increased risk of developing leukemia. (Curr Opin Hematol 2000 Mar;7 A rare and often fatal inherited disease in which the bone marrow fails to produce red blood cells, white blood cells, platelets, or a combination of these cells. The disease may transform into myelodysplastic syndrome or leukemia. Fanconi anemia (FA) is an autosomal recessive genetic disorder characterised clinically by progressive bone marrow failure, skeletal deformities and a predisposition to neoplasia. Patient cells manifest an extreme chromosomal instability and hypersensitivity to polyfunctional alkylating agents. It is assumed that the basic defect is related to the repair of DNA damage, in particular that of so-called DNA crosslinks. Currently there are eight complementation groups in FA (FA-A-FA-H) which indicates that at least eight independent genes can lead to FA. Three of these genes have been identified: FANCA, FANCC and FANCG. Congenital disorder affecting all bone marrow elements, resulting in anemia, leukopenia, and thrombopenia, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous chromosome breakage is a feature of this disease along with predisposition to leukemia. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD, FANCE, FANCF, FANCG. 284.0 is a specific code that can be used to specify a diagnosis 284.0 contains 52 index entries ICD-9-CM Diagnosis 284.8 Other specified aplastic anemias Suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production. Deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets. 284.8 is a specific code that can be used to specify a diagnosis 284.8 contains 27 index entries ICD-9-CM Diagnosis 284.9 Aplastic anemia unspecified A condition in which the bone marrow is unable to produce blood cells. Anemia resulting from bone marrow failure (aplastic or hypoplastic bone marrow). The production of erythroblasts and red cells is markedly decreased, and it may be associated with decreased production of granulocytes (granulocytopenia) and platelets (thrombocytopenia) as well. Aplastic anemia may be idiopathic or secondary due to bone marrow damage by toxins, radiation, or immunologic factors. -- 2004 A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. A severe sometimes chronic anemia, usually macrocytic in type, that does not respond to ordinary antianemic therapy. 284.9 is a specific code that can be used to specify a diagnosis 284.9 contains 28 index entries