2006 ICD-9-CM Volume 1 Diagnosis Codes Home > Endocrine, Nutritional And Metabolic Diseases, And Immunity Disorders 240-279 > Other Metabolic Disorders And Immunity Disorders 270-279 > ICD-9-CM Diagnosis 273 Disorders of plasma protein metabolism 273 is a non-specific code that cannot be used to specify a diagnosis ICD-9-CM Diagnosis 273.0 Polyclonal hypergammaglobulinemia 273.0 is a specific code that can be used to specify a diagnosis 273.0 contains 5 index entries ICD-9-CM Diagnosis 273.1 Monoclonal paraproteinemia Conditions characterized by the presence of a monoclonal serum (or urine) protein without clinical manifestations of plasma cell dyscrasia. 273.1 is a specific code that can be used to specify a diagnosis 273.1 contains 9 index entries ICD-9-CM Diagnosis 273.2 Other paraproteinemias A plasma cell disorder in which an abnormal amount of a single immunoglobulin is present in the serum. Paraproteinemias may be seen in conjunction with various carcinomas, chronic inflammatory and infectious conditions, and other diseases. --2004 273.2 is a specific code that can be used to specify a diagnosis 273.2 contains 10 index entries ICD-9-CM Diagnosis 273.3 Macroglobulinemia A plasma cell dyscrasia resembling leukemia with cells of lymphocytic, plasmacytic, or intermediate morphology, which secrete an IMMUNOGLOBULIN M monoclonal component. There is diffuse infiltration of bone marrow and also, in many cases, of the spleen, liver, or lymph nodes. The circulating macroglobulin produces symptoms of hyperviscosity syndrome: weakness, fatigue, bleeding disorders, and visual disturbances. Peak incidence is in the sixth and seventh decades. see also M-9671/3 (MAK-ro-GLOB-u-li-NE-me-uh) A condition in which the blood contains high levels of large proteins and is too thick to flow through small blood vessels. One type is Waldenstrom's macroglobulinemia, which is a type of cancer. A rare cancer of the lymph cells that causes the body to produce abnormal levels of plasma cells (plasmacytosis) and lymphocytes (lymphocytosis) in the bone marrow. Waldenstrom's macroglobulinemia may also cause a decrease in the number of red blood cells (anemia) and enlargement of the liver (hepatomegaly), spleen (splenomegaly), or glands (adenopathy). A clonal neoplasm of small B-lymphocytes, lymphoplasmacytoid cells, and plasma cells involving the bone marrow, lymph nodes, and the spleen. The majority of patients have a serum IgM paraprotein. Lymphoplasmacytic lymphoma/ Waldenstrom's Macroglobulinemia is a relatively rare condition accounting for approximately 2% of hematologic malignancies. Symptoms include: weakness and fatigue, hemorrhagic manifestations, weight loss and visual disturbances. Physical findings include: hepatomegaly, splenomegaly, fundic changes, adenopathy, neurologic abnormalities and purpura. The most common laboratory finding is anemia. Treatment includes: chemotherapy (alkylating agents, nucleoside analogues) radiotherapy and plasmapheresis. Bone marrow transplant is being investigated. Asymptomatic patients may be monitored without treatment until complications occur. - 2003 273.3 is a specific code that can be used to specify a diagnosis 273.3 contains 9 index entries ICD-9-CM Diagnosis 273.4 Alpha-1-antitrypsin deficiency Deficiency of the protease inhibitor ALPHA 1-ANTITRYPSIN, leading primarily to degradation of elastin of the alveolar walls, as well as other structural proteins of a variety of tissues. 273.4 is a specific code that can be used to specify a diagnosis 273.4 contains 6 index entries ICD-9-CM Diagnosis 273.8 Other disorders of plasma protein metabolism 273.8 is a specific code that can be used to specify a diagnosis 273.8 contains 17 index entries ICD-9-CM Diagnosis 273.9 Unspecified disorder of plasma protein metabolism 273.9 is a specific code that can be used to specify a diagnosis 273.9 contains 3 index entries